Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7483.066 | 0.9659 | 0.9789 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7483.066 | 0.7474 | 0.8293 | 3.2636 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7484.066 | 0.9672 | 0.9766 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7484.066 | 0.9973 | 0.9981 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7484.066 | 0.9894 | 0.9925 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7484.066 | 1.0003 | 1.0002 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7484.066 | 0.9101 | 0.9346 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7484.066 | 0.8805 | 0.9121 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7484.066 | 0.8299 | 0.8725 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7484.066 | 0.4438 | 0.5011 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7484.066 | 0.1327 | -0.0201 | 2.8312 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7485.066 | 1.0259 | 1.0142 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7485.066 | 1.0267 | 1.0146 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7485.066 | 1.0440 | 1.0240 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7485.066 | 0.9976 | 0.9987 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7485.066 | 1.1124 | 1.0597 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7485.066 | 0.9892 | 0.9940 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7485.066 | 1.0301 | 1.0165 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7485.066 | 0.6120 | 0.7463 | 3.6205 | |
| MCF 10A | NM | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7485.066 | 0.3592 | 0.5073 | 3.6205 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7486.066 | 1.1345 | 1.2569 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.000427 | uM | 7486.066 | 1.0655 | 1.1253 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.00213 | uM | 7486.066 | 0.9930 | 0.9865 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.0107 | uM | 7486.066 | 1.0732 | 1.1400 | 1.0443 | |
| MCF 10F | NM | - | AG1024 | IGF1R | RTK | 0.0533 | uM | 7486.066 | 1.0854 | 1.1633 | 1.0443 |