Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0533 | uM | 5903.066 | 1.0043 | 1.0071 | 1.1945 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 5903.066 | 1.0036 | 1.0061 | 1.1945 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 5903.066 | 1.0222 | 1.0372 | 1.1945 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 5903.066 | 0.9821 | 0.9700 | 1.1945 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 5903.066 | 0.9157 | 0.8579 | 1.1945 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5904.066 | 1.0644 | 1.1278 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 5904.066 | 0.9786 | 0.9576 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.00213 | uM | 5904.066 | 1.0543 | 1.1078 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 5904.066 | 1.0603 | 1.1197 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0533 | uM | 5904.066 | 1.0677 | 1.1343 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 5904.066 | 0.9811 | 0.9625 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 5904.066 | 0.9888 | 0.9778 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 5904.066 | 0.9783 | 0.9570 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 5904.066 | 0.9086 | 0.8185 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10385.066 | 1.0575 | 1.1527 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 10385.066 | 0.9670 | 0.9136 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.00213 | uM | 10385.066 | 1.0013 | 1.0033 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 10385.066 | 1.0468 | 1.1243 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0533 | uM | 10385.066 | 1.0085 | 1.0223 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 10385.066 | 0.9290 | 0.8150 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 10385.066 | 0.9978 | 0.9941 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 10385.066 | 0.9080 | 0.7612 | 0.7592 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 33.3 | uM | 10385.066 | 0.8637 | 0.6488 | 0.7592 | |
| BT-474 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5905.066 | 1.0683 | 1.1807 | 0.7639 | |
| BT-474 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 5905.066 | 0.9934 | 0.9826 | 0.7639 |