Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 11057.154 | 0.5810 | 0.7369 | 3.8498 | |
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11057.154 | 0.2184 | 0.3471 | 3.8498 | |
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11057.154 | 0.0791 | 0.0349 | 3.8498 | |
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11057.154 | 0.0004 | -0.7352 | 3.8498 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12269.154 | 0.7511 | 0.5022 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12269.154 | 0.6845 | 0.3690 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12269.154 | 1.0415 | 1.0830 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12269.154 | 0.9331 | 0.8663 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12269.154 | 0.6467 | 0.2933 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12269.154 | 0.6719 | 0.3438 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12269.154 | 0.3927 | -0.2147 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12269.154 | 0.2103 | -0.5795 | 0.9999 | |
| SUM185PE | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12269.154 | 0.0171 | -0.9659 | 0.9999 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000256 | uM | 10579.142 | 1.0780 | 1.1493 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00128 | uM | 10579.142 | 1.0824 | 1.1577 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0064 | uM | 10579.142 | 1.1243 | 1.2377 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.032 | uM | 10579.142 | 1.0644 | 1.1233 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.16 | uM | 10579.142 | 0.9491 | 0.9024 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.8 | uM | 10579.142 | 0.7580 | 0.5335 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 4 | uM | 10579.142 | 0.3229 | -0.3230 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 20 | uM | 10579.142 | 0.1076 | -0.7639 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 100 | uM | 10579.142 | 0.0359 | -0.9176 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12098.154 | 1.0451 | 1.0928 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12098.154 | 1.0793 | 1.1633 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12098.154 | 1.0186 | 1.0383 | 0.9724 |