Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.16 | uM | 10581.142 | 0.9884 | 0.9706 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.8 | uM | 10581.142 | 0.9433 | 0.8573 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 4 | uM | 10581.142 | 0.6616 | 0.1843 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 20 | uM | 10581.142 | 0.0289 | -0.9776 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 100 | uM | 10581.142 | 0.0063 | -0.9968 | 0.7885 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 11854.154 | 0.9390 | 0.9066 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 11854.154 | 0.9618 | 0.9417 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 11854.154 | 0.9541 | 0.9297 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 11854.154 | 1.0032 | 1.0048 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 11854.154 | 0.9020 | 0.8491 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 11854.154 | 0.9233 | 0.8822 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 11854.154 | 0.8840 | 0.8209 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 11854.154 | 0.4068 | 0.0090 | 1.3146 | |
| BT-20 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 11854.154 | 0.0129 | -0.9271 | 1.3146 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12056.154 | 0.9198 | 0.8252 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12056.154 | 0.9634 | 0.9201 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12056.154 | 0.9505 | 0.8919 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12056.154 | 0.9931 | 0.9849 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12056.154 | 0.8251 | 0.6204 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12056.154 | 0.7411 | 0.4407 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12056.154 | 0.5517 | 0.0431 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12056.154 | 0.3343 | -0.3973 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12056.154 | 0.0103 | -0.9867 | 0.9136 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12178.154 | 1.0216 | 1.0843 | 0.5170 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12178.154 | 1.0505 | 1.2001 | 0.5170 |