Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10999.154 | 0.0132 | -0.9958 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10999.154 | 0.0165 | -0.9942 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10999.154 | 0.0166 | -0.9941 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12379.167 | 1.0529 | 1.2081 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12379.167 | 1.0249 | 1.0968 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12379.167 | 1.0249 | 1.0968 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12379.167 | 0.9269 | 0.7288 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12379.167 | 0.6753 | -0.0584 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12379.167 | 0.1322 | -0.9588 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12379.167 | 0.0145 | -0.9994 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12379.167 | 0.0188 | -0.9990 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12379.167 | 0.0155 | -0.9993 | 0.5212 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10938.154 | 0.9049 | 0.8171 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10938.154 | 0.7539 | 0.5253 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 10938.154 | 0.6176 | 0.2596 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10938.154 | 1.0249 | 1.0478 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10938.154 | 0.7104 | 0.4408 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 10938.154 | 0.0275 | -0.9362 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10938.154 | 0.0116 | -0.9722 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10938.154 | 0.0092 | -0.9778 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10938.154 | 0.0136 | -0.9676 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12333.167 | 0.9668 | 0.9031 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12333.167 | 0.9401 | 0.8266 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12333.167 | 0.9969 | 0.9909 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12333.167 | 0.8648 | 0.6159 | 0.6809 |