Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7531.098 | 0.9454 | 0.9680 | 3.4793 | |
| SUM159PT | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7531.098 | 1.0302 | 1.0172 | 3.4793 | |
| SUM159PT | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7531.098 | 0.9627 | 0.9783 | 3.4793 | |
| SUM159PT | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7531.098 | 0.9993 | 0.9996 | 3.4793 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7532.098 | 0.9899 | 0.9711 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7532.098 | 0.9263 | 0.7927 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7532.098 | 0.9400 | 0.8305 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7532.098 | 0.9600 | 0.8865 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7532.098 | 0.9750 | 0.9290 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7532.098 | 0.9445 | 0.8431 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7532.098 | 0.9376 | 0.8238 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7532.098 | 0.9747 | 0.9279 | 0.6992 | |
| SUM185PE | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7532.098 | 0.9558 | 0.8747 | 0.6992 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7533.098 | 1.0479 | 1.1125 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7533.098 | 1.0854 | 1.2014 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7533.098 | 1.1058 | 1.2497 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7533.098 | 1.0956 | 1.2255 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7533.098 | 1.0304 | 1.0714 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7533.098 | 1.0304 | 1.0714 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7533.098 | 0.8012 | 0.5431 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7533.098 | 0.4918 | -0.1284 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7533.098 | 0.4809 | -0.1508 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7534.098 | 1.0394 | 1.0850 | 0.9286 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7534.098 | 1.0156 | 1.0336 | 0.9286 | |
| SUM225CWN | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7534.098 | 1.0421 | 1.0907 | 0.9286 |