Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7456.098 | 0.9835 | 0.9809 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7456.098 | 0.9906 | 0.9892 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7456.098 | 0.9939 | 0.9930 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7456.098 | 0.9973 | 0.9969 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7456.098 | 0.9620 | 0.9559 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7456.098 | 0.9194 | 0.9056 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7456.098 | 0.4429 | 0.2520 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7456.098 | 0.3511 | 0.0955 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7457.098 | 0.9838 | 0.9822 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7457.098 | 0.9923 | 0.9916 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7457.098 | 1.0071 | 1.0077 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7457.098 | 1.0359 | 1.0389 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7457.098 | 0.9927 | 0.9920 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7457.098 | 0.9682 | 0.9651 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7457.098 | 0.8927 | 0.8798 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7457.098 | 0.5933 | 0.5041 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7457.098 | 0.6725 | 0.6106 | 1.8323 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7458.098 | 1.0115 | 1.0404 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7458.098 | 0.9995 | 0.9982 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7458.098 | 1.0196 | 1.0690 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7458.098 | 1.0042 | 1.0147 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7458.098 | 0.9768 | 0.9196 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7458.098 | 0.9446 | 0.8108 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7458.098 | 0.8481 | 0.5002 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7458.098 | 0.4892 | -0.4256 | 0.5731 |