Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7453.098 | 1.0327 | 1.0444 | 1.4660 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7453.098 | 1.0512 | 1.0693 | 1.4660 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7453.098 | 0.9448 | 0.9240 | 1.4660 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7453.098 | 0.9871 | 0.9823 | 1.4660 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7453.098 | 0.9456 | 0.9252 | 1.4660 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7453.098 | 1.0442 | 1.0599 | 1.4660 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7454.098 | 0.9544 | 0.9293 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7454.098 | 0.8389 | 0.7466 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7454.098 | 0.9121 | 0.8630 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7454.098 | 0.9731 | 0.9584 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7454.098 | 0.9858 | 0.9780 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7454.098 | 0.9068 | 0.8545 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7454.098 | 0.9623 | 0.9416 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7454.098 | 0.4988 | 0.1695 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7454.098 | 0.3803 | -0.0513 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7455.098 | 0.9761 | 0.9643 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7455.098 | 0.8866 | 0.8286 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7455.098 | 0.9544 | 0.9317 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7455.098 | 0.9895 | 0.9844 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7455.098 | 1.0365 | 1.0541 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7455.098 | 0.9692 | 0.9539 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7455.098 | 1.0611 | 1.0902 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7455.098 | 0.4981 | 0.1904 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7455.098 | 0.4689 | 0.1381 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7456.098 | 1.0279 | 1.0320 | 1.7388 |