Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9933.001 | 1.1062 | 1.4972 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9933.001 | 0.8822 | 0.5178 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9933.001 | 1.0799 | 1.3685 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9933.001 | 0.8672 | 0.4616 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9933.001 | 0.5922 | -0.3686 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9933.001 | 0.4929 | -0.5784 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9933.001 | 0.5609 | -0.4398 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9933.001 | 0.6555 | -0.2105 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9933.001 | 0.4955 | -0.5736 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9953.001 | 1.1221 | 1.8133 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9953.001 | 0.9250 | 0.5875 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9953.001 | 1.1161 | 1.7687 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9953.001 | 0.8404 | 0.1952 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9953.001 | 0.6961 | -0.3161 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9953.001 | 0.6319 | -0.4863 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9953.001 | 0.6898 | -0.3341 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9953.001 | 0.7638 | -0.0996 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9953.001 | 0.5763 | -0.6091 | 0.3377 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7931.001 | 1.0178 | 1.0276 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7931.001 | 0.9610 | 0.9392 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7931.001 | 1.0220 | 1.0340 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7931.001 | 0.9741 | 0.9597 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7931.001 | 0.9009 | 0.8446 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7931.001 | 0.5569 | 0.2705 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7931.001 | 0.5878 | 0.3248 | 1.2900 |