Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7909.001 | 0.2731 | -0.1155 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7909.001 | 0.1750 | -0.3314 | 1.5909 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9759.001 | 1.0515 | 1.0866 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9759.001 | 1.0603 | 1.1014 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9759.001 | 1.0187 | 1.0316 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9759.001 | 0.9662 | 0.9427 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9759.001 | 0.5151 | 0.1417 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9759.001 | 0.1582 | -0.5790 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9759.001 | 0.1648 | -0.5642 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9759.001 | 0.2028 | -0.4805 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9759.001 | 0.2513 | -0.3774 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9760.001 | 1.0287 | 1.0594 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9760.001 | 1.0269 | 1.0557 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9760.001 | 1.0128 | 1.0264 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9760.001 | 0.9812 | 0.9612 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9760.001 | 0.7670 | 0.5206 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9760.001 | 0.2311 | -0.5598 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9760.001 | 0.2152 | -0.5911 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9760.001 | 0.2470 | -0.5285 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9760.001 | 0.2191 | -0.5834 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10127.001 | 1.0180 | 1.0420 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10127.001 | 0.9482 | 0.8796 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10127.001 | 1.0665 | 1.1560 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10127.001 | 1.0629 | 1.1476 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10127.001 | 0.5667 | 0.0307 | 0.8568 |