Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7876.001 | 0.3718 | -0.2709 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7876.001 | 0.3935 | -0.2274 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7876.001 | 0.5880 | 0.1636 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7876.001 | 0.7795 | 0.5513 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7876.001 | 0.5326 | 0.0520 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7877.001 | 0.9685 | 0.8584 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7877.001 | 1.1061 | 1.5196 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7877.001 | 0.8374 | 0.3322 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7877.001 | 0.4733 | -0.6395 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7877.001 | 0.4838 | -0.6209 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7877.001 | 0.5301 | -0.5326 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7877.001 | 0.7228 | -0.0491 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7877.001 | 0.8438 | 0.3554 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7877.001 | 0.2680 | -0.9020 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10077.001 | 1.0121 | 1.0409 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10077.001 | 1.0921 | 1.3197 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10077.001 | 0.9639 | 0.8799 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10077.001 | 1.0157 | 1.0532 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10077.001 | 0.9048 | 0.6899 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10077.001 | 0.9201 | 0.7384 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10077.001 | 1.0656 | 1.2256 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10077.001 | 0.9602 | 0.8677 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10077.001 | 0.1775 | -0.8911 | 0.5941 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7879.001 | 0.9690 | 0.9664 | 1.8589 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7879.001 | 0.9087 | 0.8996 | 1.8589 |