Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7839.001 | 0.9224 | 0.9164 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7839.001 | 0.1774 | -0.1981 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7839.001 | 0.1889 | -0.1711 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7839.001 | 0.1914 | -0.1654 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 7839.001 | 0.3284 | 0.1102 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 7839.001 | 0.3473 | 0.1436 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 7839.001 | 0.2657 | -0.0073 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 7839.001 | 0.0763 | -0.4867 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9386.001 | 0.9640 | 0.9454 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9386.001 | 1.0580 | 1.0870 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9386.001 | 0.9424 | 0.9124 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9386.001 | 0.5383 | 0.2530 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9386.001 | 0.1515 | -0.5190 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 0.267 | uM | 9386.001 | 0.2479 | -0.3025 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 1.33 | uM | 9386.001 | 0.2965 | -0.2014 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 6.67 | uM | 9386.001 | 0.1865 | -0.4374 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 33.3 | uM | 9386.001 | 0.0903 | -0.6745 | 1.3243 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7841.001 | 0.9638 | 0.8685 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7841.001 | 0.9252 | 0.7328 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7841.001 | 0.6726 | -0.0375 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7841.001 | 0.6348 | -0.1347 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7841.001 | 0.6449 | -0.1093 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7841.001 | 0.7372 | 0.1398 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7841.001 | 0.7808 | 0.2674 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7841.001 | 0.6154 | -0.1828 | 0.5424 |