Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 9244.001 | 0.3380 | -0.7297 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 9244.001 | 0.2068 | -0.8907 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 9244.001 | 0.1976 | -0.8996 | 0.5421 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7813.001 | 1.2554 | 1.7266 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7813.001 | 1.0240 | 1.0657 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7813.001 | 1.2939 | 1.8414 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7813.001 | 1.1222 | 1.3403 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7813.001 | 1.0858 | 1.2376 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7813.001 | 0.9665 | 0.9094 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7813.001 | 0.9942 | 0.9842 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7813.001 | 0.7184 | 0.2745 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7813.001 | 0.0418 | -0.9735 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7816.001 | 1.0676 | 1.1318 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 7816.001 | 1.0098 | 1.0191 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 7816.001 | 1.0761 | 1.1484 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 7816.001 | 0.9484 | 0.8992 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 7816.001 | 0.8232 | 0.6541 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 7816.001 | 0.8308 | 0.6690 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 7816.001 | 0.6442 | 0.3019 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 7816.001 | 0.4238 | -0.1351 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 7816.001 | 0.0087 | -0.9806 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9254.001 | 0.9218 | 0.6305 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 9254.001 | 0.9028 | 0.5474 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 9254.001 | 0.9918 | 0.9590 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 9254.001 | 1.0579 | 1.3036 | 0.3986 |