Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9953.011 | 0.9847 | 0.9352 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9953.011 | 1.0216 | 1.0933 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9953.011 | 0.9842 | 0.9335 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9953.011 | 0.9939 | 0.9740 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9953.011 | 1.0526 | 1.2306 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9953.011 | 0.8678 | 0.4790 | 0.4697 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7931.011 | 1.0195 | 1.0300 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7931.011 | 0.9656 | 0.9469 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7931.011 | 0.9714 | 0.9558 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7931.011 | 0.7066 | 0.5310 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7931.011 | 0.6850 | 0.4948 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7931.011 | 0.6675 | 0.4652 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7931.011 | 0.6573 | 0.4480 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7931.011 | 0.6298 | 0.4011 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7931.011 | 0.5810 | 0.3168 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7932.011 | 1.0135 | 1.0300 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7932.011 | 1.0303 | 1.0673 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7932.011 | 0.9504 | 0.8903 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7932.011 | 0.6445 | 0.2293 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7932.011 | 0.6576 | 0.2570 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7932.011 | 0.6293 | 0.1971 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7932.011 | 0.6263 | 0.1908 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7932.011 | 0.5476 | 0.0261 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7932.011 | 0.5093 | -0.0531 | 0.9025 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9972.011 | 1.2348 | 1.5011 | 0.9432 |