Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7907.011 | 0.5138 | 0.2480 | 1.4119 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7909.075 | 1.0842 | 1.1085 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.00924 | uM | 7909.075 | 0.9729 | 0.9644 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7909.075 | 1.0949 | 1.1221 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7909.075 | 0.5930 | 0.4215 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7909.075 | 0.6702 | 0.5399 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7909.075 | 0.5809 | 0.4026 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7909.075 | 0.6709 | 0.5409 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7909.075 | 0.6491 | 0.5081 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 722 | uM | 7909.075 | 0.5460 | 0.3469 | 1.5307 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9759.011 | 1.0103 | 1.0170 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9759.011 | 0.9809 | 0.9685 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9759.011 | 0.7779 | 0.6265 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9759.011 | 0.2197 | -0.4253 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9759.011 | 0.2380 | -0.3862 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9759.011 | 0.2659 | -0.3276 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9759.011 | 0.3114 | -0.2343 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9759.011 | 0.3123 | -0.2324 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9759.011 | 0.2269 | -0.4098 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9760.011 | 1.0836 | 1.1738 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9760.011 | 1.1025 | 1.2132 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9760.011 | 0.8761 | 0.7434 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9760.011 | 0.5759 | 0.1279 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9760.011 | 0.5821 | 0.1404 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9760.011 | 0.5464 | 0.0679 | 0.9634 |