Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 722 | uM | 9024.075 | 0.0510 | -0.2851 | 2.8935 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 10261.011 | 1.0045 | 1.0037 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 10261.011 | 0.9355 | 0.9460 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 10261.011 | 0.5479 | 0.5618 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 10261.011 | 0.2354 | 0.1035 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 10261.011 | 0.1654 | -0.0454 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 10261.011 | 0.1527 | -0.0764 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 10261.011 | 0.1442 | -0.0978 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 10261.011 | 0.1186 | -0.1673 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 10261.011 | 0.1167 | -0.1730 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0185 | uM | 10261.131 | 0.1973 | 0.0167 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0924 | uM | 10261.131 | 0.2081 | 0.0395 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.462 | uM | 10261.131 | 0.1924 | 0.0062 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 2.31 | uM | 10261.131 | 0.1757 | -0.0313 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 11.6 | uM | 10261.131 | 0.1494 | -0.0945 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 57.8 | uM | 10261.131 | 0.1397 | -0.1194 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 289 | uM | 10261.131 | 0.1483 | -0.0972 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1440 | uM | 10261.131 | 0.1239 | -0.1624 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7220 | uM | 10261.131 | 0.0740 | -0.3245 | 2.3992 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9210.011 | 0.9823 | 0.9624 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9210.011 | 1.0164 | 1.0347 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9210.011 | 0.9005 | 0.7899 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9210.011 | 0.7749 | 0.5264 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9210.011 | 0.7785 | 0.5339 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9210.011 | 0.7813 | 0.5400 | 0.9440 |