Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7931.04 | 1.0774 | 1.1200 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7931.04 | 1.0359 | 1.0559 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7931.04 | 0.5325 | 0.2220 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7931.04 | 0.4226 | 0.0198 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7931.04 | 0.4207 | 0.0163 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7931.04 | 0.4394 | 0.0514 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7931.04 | 0.4006 | -0.0219 | 1.2790 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9958.012 | 1.0127 | 1.0446 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9958.012 | 1.0111 | 1.0391 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9958.012 | 1.0284 | 1.1006 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9958.012 | 0.9431 | 0.8047 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9958.012 | 0.5958 | -0.1931 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9958.012 | 0.5433 | -0.3135 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9958.012 | 0.5225 | -0.3590 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9958.012 | 0.5217 | -0.3607 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9958.012 | 0.5039 | -0.3984 | 0.5705 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9972.012 | 0.9841 | 0.9734 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9972.012 | 1.0219 | 1.0365 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9972.012 | 0.9493 | 0.9151 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9972.012 | 0.7286 | 0.5357 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9972.012 | 0.4715 | 0.0682 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9972.012 | 0.4131 | -0.0435 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9972.012 | 0.4200 | -0.0302 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9972.012 | 0.3829 | -0.1022 | 1.1986 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9972.012 | 0.3814 | -0.1050 | 1.1986 |