Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9551.012 | 0.9781 | 0.9837 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9551.012 | 1.0510 | 1.0371 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9551.012 | 0.5664 | 0.6210 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9551.012 | 0.0506 | -0.3360 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9551.012 | 0.0688 | -0.2563 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9551.012 | 0.0682 | -0.2585 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9551.012 | 0.0663 | -0.2663 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9551.012 | 0.0617 | -0.2855 | 2.7057 | |
| MCF 10A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9551.012 | 0.0475 | -0.3517 | 2.7057 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9566.012 | 1.0968 | 1.0845 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9566.012 | 1.0199 | 1.0177 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9566.012 | 0.6726 | 0.6746 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9566.012 | 0.1212 | -0.2225 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9566.012 | 0.1046 | -0.2722 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9566.012 | 0.1014 | -0.2823 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9566.012 | 0.0932 | -0.3089 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9566.012 | 0.0821 | -0.3469 | 2.2335 | |
| MCF 10F | NM | - | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9566.012 | 0.0760 | -0.3693 | 2.2335 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7873.04 | 1.0549 | 1.0498 | 2.1738 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7873.04 | 0.9974 | 0.9976 | 2.1738 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7873.04 | 0.9494 | 0.9528 | 2.1738 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7873.04 | 0.1435 | -0.1813 | 2.1738 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7873.04 | 0.0714 | -0.4060 | 2.1738 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7873.04 | 0.0638 | -0.4362 | 2.1738 | |
| MCF12A | NM | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7873.04 | 0.0618 | -0.4441 | 2.1738 |