Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7813.012 | 0.6077 | 0.2442 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7813.012 | 0.5265 | 0.0852 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7813.012 | 0.4475 | -0.0705 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7814.04 | 0.9994 | 0.9986 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7814.04 | 1.0194 | 1.0447 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7814.04 | 1.0103 | 1.0237 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7814.04 | 0.8388 | 0.6346 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7814.04 | 0.6236 | 0.1631 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7814.04 | 0.5527 | 0.0126 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7814.04 | 0.5207 | -0.0545 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7814.04 | 0.4766 | -0.1457 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7814.04 | 0.4640 | -0.1717 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9254.049 | 1.1885 | 1.4376 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9254.049 | 1.1698 | 1.3936 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9254.049 | 1.1950 | 1.4527 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9254.049 | 0.7855 | 0.5168 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9254.049 | 0.7855 | 0.5168 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9254.049 | 0.7342 | 0.4039 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9254.049 | 0.8070 | 0.5644 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9254.049 | 0.6348 | 0.1882 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9254.049 | 0.5259 | -0.0421 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9258.024 | 1.0502 | 1.1954 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9258.024 | 0.9932 | 0.9741 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9258.024 | 1.0602 | 1.2356 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9258.024 | 0.7055 | 0.0293 | 0.5251 |