Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5908.084 | 0.9969 | 0.9873 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5908.084 | 0.9026 | 0.6207 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5908.084 | 0.0338 | -0.9981 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5908.084 | 0.0162 | -0.9996 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5908.084 | 0.0147 | -0.9997 | 0.4873 | |
| BT-483 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5908.084 | 0.0066 | -0.9999 | 0.4873 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5909.085 | 1.0720 | 1.0456 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5909.085 | 1.0777 | 1.0491 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5909.085 | 1.0299 | 1.0192 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5909.085 | 1.0293 | 1.0188 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5909.085 | 1.0121 | 1.0078 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5909.085 | 0.8471 | 0.8953 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5909.085 | 0.0640 | -0.1795 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5909.085 | 0.0068 | -0.6035 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5909.085 | 0.0033 | -0.6849 | 3.0853 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5910.084 | 1.0470 | 1.0298 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5910.084 | 1.0699 | 1.0439 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5910.084 | 1.0357 | 1.0227 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5910.084 | 1.0799 | 1.0501 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5910.084 | 0.9939 | 0.9960 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5910.084 | 0.8718 | 0.9137 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5910.084 | 0.0277 | -0.3691 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5910.084 | 0.0032 | -0.6861 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5910.084 | 0.0005 | -0.8266 | 3.1096 | |
| CAMA-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5911.084 | 1.0069 | 1.0135 | 1.0262 |