Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5899.084 | 0.9807 | 0.9653 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5899.084 | 0.9666 | 0.9399 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5899.084 | 1.0074 | 1.0132 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5899.084 | 0.9749 | 0.9550 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5899.084 | 0.9996 | 0.9993 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5899.084 | 0.8463 | 0.7218 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5899.084 | 0.0090 | -0.9709 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5899.084 | 0.0070 | -0.9766 | 1.1144 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5899.084 | 0.0072 | -0.9760 | 1.1144 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5900.085 | 1.0283 | 1.0213 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5900.085 | 0.9689 | 0.9762 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5900.085 | 0.9740 | 0.9801 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5900.085 | 0.9426 | 0.9557 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5900.085 | 0.8608 | 0.8896 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5900.085 | 0.3874 | 0.3963 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5900.085 | 0.0834 | -0.2197 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5900.085 | 0.0072 | -0.6922 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5900.085 | 0.0047 | -0.7376 | 2.6391 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5901.084 | 1.0397 | 1.0453 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5901.084 | 0.9980 | 0.9977 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5901.084 | 1.0045 | 1.0051 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5901.084 | 0.9942 | 0.9933 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5901.084 | 0.7347 | 0.6753 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5901.084 | 0.2369 | -0.1259 | 1.7402 | |
| AU565 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5901.084 | 0.0245 | -0.7627 | 1.7402 |