Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 10266.001 | 0.4146 | -0.3222 | 0.8138 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9708.001 | 1.1023 | 1.2016 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9708.001 | 1.0329 | 1.0649 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9708.001 | 1.1072 | 1.2112 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9708.001 | 0.8096 | 0.6240 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9708.001 | 0.9110 | 0.8244 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9708.001 | 0.8979 | 0.7985 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9708.001 | 0.7797 | 0.5649 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9708.001 | 0.5884 | 0.1856 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9708.001 | 0.0709 | -0.8528 | 1.0142 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9723.001 | 1.0870 | 1.1856 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9723.001 | 0.9738 | 0.9443 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9723.001 | 1.0678 | 1.1445 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9723.001 | 0.9281 | 0.8475 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9723.001 | 0.9076 | 0.8039 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9723.001 | 0.8577 | 0.6986 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9723.001 | 0.8044 | 0.5866 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9723.001 | 0.6958 | 0.3597 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9723.001 | 0.0254 | -0.9598 | 0.9400 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7904.001 | 1.1577 | 1.2219 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7904.001 | 0.8526 | 0.7834 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7904.001 | 1.1269 | 1.1793 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7904.001 | 0.8502 | 0.7799 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7904.001 | 0.2575 | -0.2455 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7904.001 | 0.1757 | -0.4268 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7904.001 | 0.2328 | -0.2983 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7904.001 | 0.4069 | 0.0481 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7904.001 | 0.1210 | -0.5617 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7905.001 | 1.3901 | 2.1151 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7905.001 | 0.9366 | 0.8312 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7905.001 | 1.2457 | 1.6878 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7905.001 | 0.9650 | 0.9065 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7905.001 | 0.0983 | -0.9118 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7905.001 | 0.0830 | -0.9297 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7905.001 | 0.1269 | -0.8755 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7905.001 | 0.3874 | -0.4415 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7905.001 | 0.0483 | -0.9661 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7906.001 | 1.0037 | 1.0131 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7906.001 | 0.8506 | 0.5046 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7906.001 | 1.1170 | 1.4299 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7906.001 | 0.9544 | 0.8422 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7906.001 | 0.1014 | -0.9643 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7906.001 | 0.0802 | -0.9764 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7906.001 | 0.1262 | -0.9476 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7906.001 | 0.2275 | -0.8521 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7906.001 | 0.0713 | -0.9808 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7907.001 | 1.1652 | 1.2435 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7907.001 | 0.9379 | 0.9059 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7907.001 | 1.1965 | 1.2886 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7907.001 | 0.9309 | 0.8953 | 1.3308 |