Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12580.169 | 0.2073 | -0.0372 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12580.169 | 0.1157 | -0.2656 | 2.1524 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 11056.15 | 0.9779 | 0.9853 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 11056.15 | 0.9544 | 0.9693 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 11056.15 | 1.0389 | 1.0254 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 11056.15 | 0.9847 | 0.9898 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 11056.15 | 1.0171 | 1.0113 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 11056.15 | 0.9401 | 0.9595 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 11056.15 | 0.8638 | 0.9054 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 11056.15 | 0.5178 | 0.6084 | 3.0207 | ||
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 11056.15 | 0.4866 | 0.5757 | 3.0207 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12254.16 | 1.0833 | 1.1173 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 0.000853 | uM | 12254.16 | 1.0811 | 1.1143 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 0.00427 | uM | 12254.16 | 1.0503 | 1.0712 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12254.16 | 1.0210 | 1.0298 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12254.16 | 1.0765 | 1.1079 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12254.16 | 1.1334 | 1.1868 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12254.16 | 1.1352 | 1.1892 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12254.16 | 1.0750 | 1.1058 | 1.4029 | ||
| MCF 10F | NM | - | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12254.16 | 0.9228 | 0.8887 | 1.4029 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10817.15 | 1.0339 | 1.0492 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10817.15 | 0.9620 | 0.9442 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10817.15 | 1.0203 | 1.0295 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10817.15 | 0.9770 | 0.9663 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10817.15 | 0.9972 | 0.9959 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10817.15 | 1.0018 | 1.0026 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10817.15 | 0.9675 | 0.9523 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10817.15 | 0.6827 | 0.5134 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10817.15 | 0.6878 | 0.5215 | 1.3689 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12365.169 | 1.0366 | 1.0332 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.000853 | uM | 12365.169 | 0.9934 | 0.9939 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.00427 | uM | 12365.169 | 0.9764 | 0.9783 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12365.169 | 1.0076 | 1.0070 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12365.169 | 1.0467 | 1.0422 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12365.169 | 1.0731 | 1.0657 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12365.169 | 0.8745 | 0.8808 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12365.169 | 0.7506 | 0.7538 | 2.1831 | ||
| MCF12A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12365.169 | 0.7231 | 0.7240 | 2.1831 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10997.15 | 0.8554 | 0.7920 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10997.15 | 0.9545 | 0.9356 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10997.15 | 1.0010 | 1.0014 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10997.15 | 0.9882 | 0.9833 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10997.15 | 0.9015 | 0.8593 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10997.15 | 0.8961 | 0.8515 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10997.15 | 0.8874 | 0.8388 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10997.15 | 0.7992 | 0.7083 | 1.4218 | ||
| MCF7 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10997.15 | 0.6304 | 0.4457 | 1.4218 | ||
| MDA-MB-134-VI | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10519.138 | 0.9834 | 0.9686 | 1.0592 | ||
| MDA-MB-134-VI | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10519.138 | 0.9897 | 0.9806 | 1.0592 | ||
| MDA-MB-134-VI | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10519.138 | 0.9721 | 0.9473 | 1.0592 |