Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10873.15 | 1.0289 | 1.0483 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10873.15 | 1.1017 | 1.1687 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10873.15 | 0.9771 | 0.9616 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10873.15 | 0.9529 | 0.9210 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10873.15 | 0.6222 | 0.3448 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10873.15 | 0.4658 | 0.0558 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10873.15 | 0.5094 | 0.1377 | 1.1958 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12400.169 | 0.9431 | 0.9080 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.000853 | uM | 12400.169 | 0.9238 | 0.8766 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.00427 | uM | 12400.169 | 0.9162 | 0.8642 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12400.169 | 0.9311 | 0.8885 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12400.169 | 0.9198 | 0.8700 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12400.169 | 0.8723 | 0.7922 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12400.169 | 0.3788 | -0.0829 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12400.169 | 0.3867 | -0.0677 | 1.2449 | ||
| HCC70 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12400.169 | 0.4360 | 0.0266 | 1.2449 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10694.15 | 1.0058 | 1.0052 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10694.15 | 0.9817 | 0.9834 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10694.15 | 1.0098 | 1.0088 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10694.15 | 0.9810 | 0.9828 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10694.15 | 0.9453 | 0.9499 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10694.15 | 1.0017 | 1.0015 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10694.15 | 0.7432 | 0.7496 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10694.15 | 0.4829 | 0.4407 | 2.2191 | ||
| Hs 578T | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10694.15 | 0.4429 | 0.3856 | 2.2191 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10816.15 | 1.2067 | 2.7169 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000427 | uM | 10816.15 | 1.4683 | 6.1020 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.00213 | uM | 10816.15 | 1.2333 | 2.9943 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0107 | uM | 10816.15 | 1.3861 | 4.8724 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0533 | uM | 10816.15 | 1.4003 | 5.0731 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.267 | uM | 10816.15 | 1.0722 | 1.5169 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 1.33 | uM | 10816.15 | 0.8720 | 0.2730 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 6.67 | uM | 10816.15 | 0.5234 | -0.7637 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 33.3 | uM | 10816.15 | 0.3061 | -0.9598 | 0.3031 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12319.169 | 0.8585 | 0.7155 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.000853 | uM | 12319.169 | 0.9247 | 0.8487 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.00427 | uM | 12319.169 | 0.8517 | 0.7020 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12319.169 | 0.7535 | 0.5049 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12319.169 | 0.8720 | 0.7427 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12319.169 | 0.7588 | 0.5153 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12319.169 | 0.4202 | -0.1634 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 13.3 | uM | 12319.169 | 0.3175 | -0.3688 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 66.7 | uM | 12319.169 | 0.2647 | -0.4744 | 0.9948 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.000171 | uM | 12580.169 | 1.0945 | 1.0857 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.000853 | uM | 12580.169 | 0.9942 | 0.9946 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.00427 | uM | 12580.169 | 1.0622 | 1.0569 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.0213 | uM | 12580.169 | 1.0320 | 1.0295 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.107 | uM | 12580.169 | 1.0440 | 1.0404 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 0.533 | uM | 12580.169 | 0.9489 | 0.9519 | 2.1524 | ||
| MB 157 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 2.67 | uM | 12580.169 | 0.4482 | 0.3775 | 2.1524 |