Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 2.67 | uM | 7457.074 | 0.4813 | 0.2844 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 13.3 | uM | 7457.074 | 0.1812 | -0.2891 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 66.7 | uM | 7457.074 | 0.0373 | -0.7269 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7457.074 | 0.0288 | -0.7665 | 1.6514 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7458.074 | 1.0443 | 1.2206 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7458.074 | 1.0231 | 1.1133 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7458.074 | 1.0311 | 1.1536 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7458.074 | 0.9721 | 0.8678 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7458.074 | 0.9192 | 0.6314 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7458.074 | 0.7428 | -0.0251 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7458.074 | 0.4650 | -0.6856 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7458.074 | 0.4668 | -0.6826 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7458.074 | 0.3636 | -0.8265 | 0.4138 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7462.074 | 1.0123 | 1.0404 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7462.074 | 0.9331 | 0.7862 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7462.074 | 0.9928 | 0.9764 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7462.074 | 0.9621 | 0.8777 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7462.074 | 0.8490 | 0.5311 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7462.074 | 0.9010 | 0.6869 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7462.074 | 0.7629 | 0.2858 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7462.074 | 0.6141 | -0.0976 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7462.074 | 0.4930 | -0.3695 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7463.074 | 1.0220 | 1.0974 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7463.074 | 1.0014 | 1.0061 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7463.074 | 0.9878 | 0.9472 | 0.4574 |