Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Etoposide | TOP2 | TOP | 333 | uM | 7432.074 | 0.0257 | -0.9717 | 0.8598 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7435.074 | 0.9673 | 0.9239 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7435.074 | 1.0086 | 1.0202 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7435.074 | 0.9719 | 0.9347 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7435.074 | 0.9012 | 0.7715 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7435.074 | 0.9302 | 0.8383 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7435.074 | 0.7491 | 0.4283 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 13.3 | uM | 7435.074 | 0.5483 | -0.0074 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 66.7 | uM | 7435.074 | 0.4409 | -0.2300 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 333 | uM | 7435.074 | 0.2904 | -0.5267 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7436.074 | 0.9597 | 0.9336 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7436.074 | 0.9609 | 0.9355 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7436.074 | 0.9725 | 0.9547 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7436.074 | 0.9335 | 0.8900 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7436.074 | 0.9154 | 0.8599 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 2.67 | uM | 7436.074 | 0.7333 | 0.5501 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 13.3 | uM | 7436.074 | 0.5478 | 0.2198 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 66.7 | uM | 7436.074 | 0.3936 | -0.0701 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 333 | uM | 7436.074 | 0.2359 | -0.3894 | 1.2173 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7437.074 | 1.0139 | 1.0751 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7437.074 | 1.0143 | 1.0773 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7437.074 | 1.0629 | 1.3538 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7437.074 | 1.0135 | 1.0731 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7437.074 | 1.0503 | 1.2797 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7437.074 | 1.0288 | 1.1573 | 0.3747 |