Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7886.05 | 0.0105 | -0.9986 | 0.6254 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7892.037 | 0.9333 | 0.9459 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7892.037 | 0.9674 | 0.9739 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7892.037 | 0.9674 | 0.9739 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7892.037 | 1.0051 | 1.0040 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7892.037 | 0.9979 | 0.9983 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7892.037 | 0.8258 | 0.8536 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7892.037 | 0.3008 | 0.2413 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7892.037 | 0.2215 | 0.0992 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7892.037 | 0.1706 | -0.0092 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7893.05 | 1.0395 | 1.0351 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7893.05 | 1.0196 | 1.0175 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7893.05 | 1.0664 | 1.0587 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7893.05 | 1.0440 | 1.0391 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7893.05 | 1.0048 | 1.0043 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7893.05 | 0.8060 | 0.8152 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7893.05 | 0.3334 | 0.2208 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7893.05 | 0.2966 | 0.1584 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7893.05 | 0.1750 | -0.0860 | 2.2255 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7505.05 | 1.0334 | 1.0741 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7505.05 | 1.0627 | 1.1392 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7505.05 | 1.0025 | 1.0055 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7505.05 | 0.9970 | 0.9934 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7505.05 | 0.1676 | -0.7229 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7505.05 | 0.1319 | -0.7874 | 0.9037 |