Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 7892.043 | 1.0696 | 1.0525 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 7892.043 | 0.9973 | 0.9979 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 7892.043 | 0.9825 | 0.9864 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 7892.043 | 1.0462 | 1.0351 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 7892.043 | 0.9004 | 0.9207 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7893.007 | 1.0705 | 1.0604 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7893.007 | 1.0932 | 1.0793 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7893.007 | 1.0381 | 1.0329 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7893.007 | 1.1067 | 1.0905 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 7893.007 | 1.1348 | 1.1135 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 7893.007 | 1.0901 | 1.0768 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 7893.007 | 0.9789 | 0.9815 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 7893.007 | 0.9591 | 0.9639 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 7893.007 | 0.7015 | 0.7132 | 2.2909 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7505.078 | 1.0023 | 1.0039 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7505.078 | 0.9809 | 0.9677 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7505.078 | 1.0474 | 1.0797 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 7505.078 | 0.9801 | 0.9664 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 7505.078 | 1.0184 | 1.0310 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 7505.078 | 0.9824 | 0.9702 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 7505.078 | 0.9493 | 0.9141 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 7505.078 | 0.8057 | 0.6666 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 7505.078 | 0.6615 | 0.4110 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7896.007 | 0.9723 | 0.9505 | 1.1203 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7896.007 | 1.0219 | 1.0391 | 1.1203 |