Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10147.034 | 1.0660 | 1.0552 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10147.034 | 1.1375 | 1.1129 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.118 | uM | 10147.034 | 1.1281 | 1.1054 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.59 | uM | 10147.034 | 1.1223 | 1.1008 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 2.95 | uM | 10147.034 | 0.6166 | 0.6276 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 14.8 | uM | 10147.034 | 0.4123 | 0.3712 | 2.3470 | |
| HMT-3522 T4-2 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 73.8 | uM | 10147.034 | 0.0516 | -0.4345 | 2.3470 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7863.007 | 1.0648 | 1.0880 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7863.007 | 1.0116 | 1.0158 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7863.007 | 1.0766 | 1.1039 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7863.007 | 1.0331 | 1.0452 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 7863.007 | 1.0239 | 1.0327 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 7863.007 | 1.0331 | 1.0452 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 7863.007 | 1.0489 | 1.0666 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 7863.007 | 0.9940 | 0.9918 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 7863.007 | 0.7898 | 0.7011 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9511.034 | 1.0199 | 1.0356 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9511.034 | 1.0177 | 1.0316 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9511.034 | 0.8981 | 0.8167 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9511.034 | 1.0493 | 1.0880 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.118 | uM | 9511.034 | 0.9699 | 0.9461 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.59 | uM | 9511.034 | 0.9753 | 0.9557 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 2.95 | uM | 9511.034 | 0.9304 | 0.8750 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 14.8 | uM | 9511.034 | 0.7118 | 0.4754 | 1.1177 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 73.8 | uM | 9511.034 | 0.1542 | -0.6245 | 1.1177 |