Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 10261.131 | 0.7546 | 0.7785 | 2.3992 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 10261.131 | 0.5570 | 0.5671 | 2.3992 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 10261.131 | 0.0976 | -0.2417 | 2.3992 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 10261.131 | 0.0345 | -0.5085 | 2.3992 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 10261.131 | 0.0280 | -0.5492 | 2.3992 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9210.131 | 1.0447 | 1.0995 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9210.131 | 0.9711 | 0.9359 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9210.131 | 0.9641 | 0.9205 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9210.131 | 1.0134 | 1.0297 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9210.131 | 0.9795 | 0.9545 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9210.131 | 1.0018 | 1.0041 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9210.131 | 0.9805 | 0.9567 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9210.131 | 0.6732 | 0.2887 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9210.131 | 0.0419 | -0.9410 | 0.9004 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7807.017 | 0.9962 | 0.9966 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7807.017 | 1.0441 | 1.0396 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7807.017 | 1.0342 | 1.0308 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7807.017 | 1.0443 | 1.0398 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7807.017 | 1.0186 | 1.0168 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7807.017 | 0.9102 | 0.9163 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7807.017 | 0.6700 | 0.6673 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7807.017 | 0.0539 | -0.4695 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7807.017 | 0.9694 | 0.9720 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7808.017 | 1.1118 | 1.0897 | 2.4168 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7808.017 | 1.0691 | 1.0561 | 2.4168 |