Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12319.155 | 1.1258 | 1.2708 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12319.155 | 0.9858 | 0.9695 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12319.155 | 0.9681 | 0.9317 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12319.155 | 0.7395 | 0.4474 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12319.155 | 0.3056 | -0.4384 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12319.155 | 0.9901 | 0.9788 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12319.155 | 0.9646 | 0.9243 | 0.9333 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12580.155 | 1.0586 | 1.0517 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12580.155 | 0.9601 | 0.9639 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12580.155 | 0.9562 | 0.9603 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12580.155 | 0.9329 | 0.9387 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12580.155 | 0.8798 | 0.8885 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.267 | uM | 12580.155 | 0.4132 | 0.3460 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 1.33 | uM | 12580.155 | 0.2797 | 0.1300 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 6.67 | uM | 12580.155 | 0.3847 | 0.3036 | 2.2315 | |
| MB 157 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 33.3 | uM | 12580.155 | 0.3803 | 0.2968 | 2.2315 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11056.155 | 0.9582 | 0.9710 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11056.155 | 1.0364 | 1.0246 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11056.155 | 0.9693 | 0.9788 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11056.155 | 0.9999 | 1.0000 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11056.155 | 0.6123 | 0.6914 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 11056.155 | 0.1994 | 0.1528 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 11056.155 | 0.1464 | 0.0375 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 11056.155 | 0.1606 | 0.0706 | 2.9269 | |
| MCF 10A | NM | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 11056.155 | 0.3403 | 0.3838 | 2.9269 |