Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 10056.034 | 0.0131 | -0.9867 | 0.8648 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7854.018 | 0.9940 | 0.9902 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 7854.018 | 0.9496 | 0.9177 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 7854.018 | 0.9255 | 0.8780 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 7854.018 | 0.5642 | 0.2558 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7854.018 | 0.6622 | 0.4305 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 7854.018 | 0.6333 | 0.3794 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 7854.018 | 0.5176 | 0.1708 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7854.018 | 0.1645 | -0.5390 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7854.018 | 0.0164 | -0.9293 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9028.018 | 0.9676 | 0.9367 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 9028.018 | 0.9620 | 0.9258 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 9028.018 | 0.8944 | 0.7936 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 9028.018 | 0.6823 | 0.3771 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 9028.018 | 0.6939 | 0.3999 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 9028.018 | 0.6170 | 0.2482 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 9028.018 | 0.5215 | 0.0592 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 9028.018 | 0.2095 | -0.5653 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 9028.018 | 0.0163 | -0.9641 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9453.125 | 1.0685 | 1.1102 | 1.2351 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 9453.125 | 0.9847 | 0.9752 | 1.2351 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 9453.125 | 1.0141 | 1.0229 | 1.2351 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 9453.125 | 0.8033 | 0.6749 | 1.2351 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 9453.125 | 0.8043 | 0.6767 | 1.2351 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 9453.125 | 0.5679 | 0.2650 | 1.2351 |