Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13091.177 | 0.7763 | 0.3932 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13091.177 | 1.0935 | 1.2723 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13091.177 | 1.0225 | 1.0646 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13091.177 | 0.9580 | 0.8813 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13091.177 | 0.5466 | -0.1558 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13091.177 | 0.0005 | -1.0000 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13091.177 | 0.0005 | -1.0000 | 0.7004 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13091.177 | 0.0005 | -1.0000 | 0.7004 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13125.177 | 1.0325 | 1.0724 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13125.177 | 0.9428 | 0.8732 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13125.177 | 1.0257 | 1.0572 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13125.177 | 1.0132 | 1.0294 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13125.177 | 1.0357 | 1.0795 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13125.177 | 0.8975 | 0.7733 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13125.177 | 0.0909 | -0.8611 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13125.177 | 0.0121 | -0.9852 | 0.8991 | |
| BT-474 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13125.177 | 0.0001 | -1.0000 | 0.8991 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12647.177 | 0.9733 | 0.9485 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12647.177 | 0.9267 | 0.8587 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12647.177 | 0.9820 | 0.9654 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12647.177 | 0.9513 | 0.9062 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12647.177 | 0.9112 | 0.8287 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12647.177 | 0.1787 | -0.6188 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12647.177 | 0.0086 | -0.9795 | 1.0387 | |
| CAMA-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12647.177 | 0.0117 | -0.9724 | 1.0387 |