Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 12003.145 | 1.0312 | 1.0649 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 12003.145 | 1.0720 | 1.1501 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 12003.145 | 1.0280 | 1.0584 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 12003.145 | 1.0966 | 1.2015 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 12003.145 | 0.8859 | 0.7631 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 12003.145 | 0.5189 | 0.0105 | 0.9611 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 11939.145 | 0.9024 | 0.8816 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 11939.145 | 0.9248 | 0.9092 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 11939.145 | 0.9467 | 0.9359 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 11939.145 | 0.9348 | 0.9215 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 11939.145 | 0.9752 | 0.9703 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 11939.145 | 0.9065 | 0.8866 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 11939.145 | 0.7954 | 0.7457 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 11939.145 | 0.3710 | 0.1096 | 1.6830 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 11939.145 | 0.3268 | 0.0290 | 1.6830 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12979.177 | 1.1919 | 1.7291 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12979.177 | 1.1096 | 1.4042 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12979.177 | 1.5032 | 3.1160 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12979.177 | 1.3533 | 2.4173 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12979.177 | 0.2654 | -0.8091 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12979.177 | 0.0006 | -1.0000 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12979.177 | 0.0009 | -1.0000 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12979.177 | 0.0007 | -1.0000 | 0.5647 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12979.177 | 0.0006 | -1.0000 | 0.5647 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13091.177 | 0.9808 | 0.9454 | 0.7004 |