Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 100 | uM | 10644.145 | 0.0128 | -0.9999 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.000256 | uM | 10874.145 | 0.9867 | 0.9689 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.00128 | uM | 10874.145 | 1.0167 | 1.0393 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0064 | uM | 10874.145 | 0.9838 | 0.9619 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.032 | uM | 10874.145 | 1.0318 | 1.0749 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.16 | uM | 10874.145 | 1.0009 | 1.0020 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.8 | uM | 10874.145 | 0.7432 | 0.4108 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 4 | uM | 10874.145 | 0.7202 | 0.3597 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 20 | uM | 10874.145 | 0.3045 | -0.5059 | 0.8505 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 100 | uM | 10874.145 | 0.2102 | -0.6805 | 0.8505 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 11851.145 | 0.9307 | 0.9057 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 11851.145 | 0.9690 | 0.9581 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 11851.145 | 0.9377 | 0.9154 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 11851.145 | 0.9003 | 0.8636 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 11851.145 | 0.9510 | 0.9336 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 11851.145 | 0.8384 | 0.7764 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 4 | uM | 11851.145 | 0.6957 | 0.5670 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 20 | uM | 11851.145 | 0.3505 | -0.0117 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 100 | uM | 11851.145 | 0.0819 | -0.6283 | 1.4873 | |
| SUM1315MO2 | TNBC | Basal B | Bosutinib | Src | nRTK | 0.000256 | uM | 10875.145 | 0.9843 | 0.9590 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | Bosutinib | Src | nRTK | 0.00128 | uM | 10875.145 | 1.0201 | 1.0529 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | Bosutinib | Src | nRTK | 0.0064 | uM | 10875.145 | 0.9712 | 0.9250 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | Bosutinib | Src | nRTK | 0.032 | uM | 10875.145 | 1.0256 | 1.0674 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | Bosutinib | Src | nRTK | 0.16 | uM | 10875.145 | 1.0306 | 1.0806 | 0.7643 | |
| SUM1315MO2 | TNBC | Basal B | Bosutinib | Src | nRTK | 0.8 | uM | 10875.145 | 0.5839 | -0.0107 | 0.7643 |