Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 11938.16 | 0.9360 | 0.8038 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 11938.16 | 0.9218 | 0.7613 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 11938.16 | 0.8999 | 0.6964 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 11938.16 | 0.7309 | 0.2260 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 11938.16 | 0.8126 | 0.4465 | 0.6405 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 11660.15 | 0.9316 | 0.8625 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 11660.15 | 0.8949 | 0.7890 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 11660.15 | 0.9439 | 0.8874 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 11660.15 | 0.9378 | 0.8750 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 11660.15 | 0.9550 | 0.9096 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 11660.15 | 0.8971 | 0.7933 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 11660.15 | 0.7935 | 0.5854 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 11660.15 | 0.7096 | 0.4171 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 11660.15 | 0.1365 | -0.7294 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12003.169 | 0.9711 | 0.9453 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12003.169 | 0.9773 | 0.9570 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12003.169 | 0.9307 | 0.8685 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12003.169 | 0.8865 | 0.7845 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12003.169 | 0.9779 | 0.9582 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12003.169 | 0.8916 | 0.7942 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12003.169 | 0.7545 | 0.5317 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12003.169 | 0.5629 | 0.1608 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12003.169 | 0.3369 | -0.2861 | 1.0562 | |
| ZR75B | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 11939.16 | 0.9352 | 0.9216 | 1.6749 | |
| ZR75B | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 11939.16 | 0.9372 | 0.9240 | 1.6749 |