Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.00128 | uM | 12098.16 | 1.0334 | 1.0697 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.0064 | uM | 12098.16 | 0.8878 | 0.7663 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.032 | uM | 12098.16 | 0.9497 | 0.8951 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.16 | uM | 12098.16 | 0.9650 | 0.9269 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 0.8 | uM | 12098.16 | 0.9381 | 0.8709 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 4 | uM | 12098.16 | 0.8150 | 0.6152 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 20 | uM | 12098.16 | 0.8007 | 0.5856 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | ZM-447439 | AURK | AURK | 100 | uM | 12098.16 | 0.3953 | -0.2414 | 0.9575 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 0.0000853 | uM | 11058.15 | 0.8944 | 0.9040 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 0.000427 | uM | 11058.15 | 0.9803 | 0.9825 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 0.00213 | uM | 11058.15 | 0.9472 | 0.9528 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 0.0107 | uM | 11058.15 | 0.9301 | 0.9371 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 0.0533 | uM | 11058.15 | 0.9506 | 0.9559 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 0.267 | uM | 11058.15 | 0.8803 | 0.8907 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 1.33 | uM | 11058.15 | 0.5720 | 0.5635 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 6.67 | uM | 11058.15 | 0.5121 | 0.4891 | 2.2684 | |
| SUM229PE | TNBC | - | ZM-447439 | AURK | AURK | 33.3 | uM | 11058.15 | 0.3627 | 0.2789 | 2.2684 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10695.15 | 0.9486 | 0.9235 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10695.15 | 0.9285 | 0.8932 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10695.15 | 0.9379 | 0.9074 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10695.15 | 1.0040 | 1.0059 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10695.15 | 0.9929 | 0.9895 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10695.15 | 0.9875 | 0.9814 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10695.15 | 0.7491 | 0.6152 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10695.15 | 0.3136 | -0.1517 | 1.3520 |