Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7435.065 | 0.1196 | -0.8350 | 0.8513 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7436.065 | 0.9433 | 0.9065 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7436.065 | 1.0140 | 1.0230 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7436.065 | 1.0000 | 1.0000 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7436.065 | 1.0545 | 1.0891 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7436.065 | 1.0370 | 1.0606 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7436.065 | 0.8712 | 0.7860 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7436.065 | 0.4487 | 0.0357 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7436.065 | 0.1871 | -0.4951 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 18700 | uM | 7436.065 | 0.0908 | -0.7212 | 1.2177 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7437.065 | 0.9521 | 0.8191 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7437.065 | 0.9854 | 0.9442 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7437.065 | 0.9682 | 0.8793 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7437.065 | 1.0159 | 1.0618 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7437.065 | 0.9861 | 0.9468 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7437.065 | 0.8165 | 0.3525 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7437.065 | 0.3147 | -0.7850 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7437.065 | 0.0409 | -0.9958 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7437.065 | 0.0366 | -0.9966 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7440.065 | 0.9322 | 0.7725 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7440.065 | 0.9189 | 0.7293 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7440.065 | 0.9313 | 0.7698 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7440.065 | 0.9759 | 0.9180 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7440.065 | 0.9472 | 0.8219 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7440.065 | 0.8697 | 0.5731 | 0.5818 |