Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 24 | uM | 11850.143 | 0.8818 | 0.8839 | 2.1044 | |
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 120 | uM | 11850.143 | 0.8889 | 0.8911 | 2.1044 | |
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 600 | uM | 11850.143 | 0.7521 | 0.7467 | 2.1044 | |
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 3000 | uM | 11850.143 | 0.1243 | -0.2574 | 2.1044 | |
| HCC38 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 15000 | uM | 11850.143 | 0.0108 | -0.7673 | 2.1044 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10873.143 | 0.9652 | 0.9453 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 10873.143 | 0.9868 | 0.9793 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 10873.143 | 0.9786 | 0.9664 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 10873.143 | 0.9754 | 0.9614 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 10873.143 | 0.9472 | 0.9170 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 10873.143 | 0.9258 | 0.8829 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 10873.143 | 0.7970 | 0.6747 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 10873.143 | 0.2652 | -0.2918 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 10873.143 | 0.0147 | -0.9263 | 1.2785 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12400.143 | 0.9330 | 0.8962 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 12400.143 | 1.0458 | 1.0702 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 12400.143 | 0.9549 | 0.9302 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 12400.143 | 1.0397 | 1.0608 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 12400.143 | 0.9505 | 0.9234 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 12400.143 | 0.9005 | 0.8451 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 600 | uM | 12400.143 | 0.8919 | 0.8316 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 3000 | uM | 12400.143 | 0.2375 | -0.3381 | 1.3002 | |
| HCC70 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 12400.143 | 0.0121 | -0.9330 | 1.3002 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10694.143 | 0.9719 | 0.9745 | 2.2259 | |
| Hs 578T | TNBC | Basal B | Valproic acid | HDAC | HDAC | 0.192 | uM | 10694.143 | 0.9024 | 0.9099 | 2.2259 |