Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 12178.158 | 1.0379 | 1.1033 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 12178.158 | 1.0849 | 1.2335 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 12178.158 | 0.9759 | 0.9351 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 12178.158 | 1.0350 | 1.0956 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 12178.158 | 0.9230 | 0.7943 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 12178.158 | 0.6116 | 0.0271 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 12178.158 | 0.9600 | 0.8923 | 0.7379 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12291.165 | 0.9939 | 0.9784 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12291.165 | 0.9258 | 0.7429 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12291.165 | 0.9665 | 0.8818 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12291.165 | 0.7976 | 0.3357 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12291.165 | 0.8825 | 0.6001 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12291.165 | 0.9068 | 0.6794 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12291.165 | 0.8644 | 0.5418 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12291.165 | 0.8517 | 0.5017 | 0.5602 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12291.165 | 0.6313 | -0.1202 | 0.5602 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10696.153 | 1.0244 | 1.0899 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10696.153 | 0.9498 | 0.8207 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10696.153 | 1.0108 | 1.0394 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10696.153 | 1.0012 | 1.0042 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10696.153 | 1.0095 | 1.0348 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10696.153 | 0.9609 | 0.8597 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10696.153 | 0.9550 | 0.8391 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10696.153 | 0.7753 | 0.2574 | 0.5484 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10696.153 | 0.5844 | -0.2491 | 0.5484 |