Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12566.165 | 0.8904 | 0.8698 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12566.165 | 0.8742 | 0.8500 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12566.165 | 0.5512 | 0.4159 | 1.7248 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12224.165 | 0.9720 | 0.9423 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12224.165 | 0.9226 | 0.8409 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12224.165 | 0.9743 | 0.9472 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12224.165 | 0.9493 | 0.8958 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12224.165 | 0.9445 | 0.8857 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12224.165 | 0.9401 | 0.8769 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12224.165 | 0.9199 | 0.8353 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12224.165 | 0.7482 | 0.4836 | 0.9714 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12224.165 | 0.6442 | 0.2719 | 0.9714 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10880.153 | 0.9615 | 0.9540 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10880.153 | 0.8944 | 0.8722 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10880.153 | 0.9895 | 0.9875 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10880.153 | 0.9712 | 0.9657 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10880.153 | 0.9429 | 0.9316 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10880.153 | 0.8189 | 0.7769 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10880.153 | 0.8501 | 0.8167 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10880.153 | 0.7442 | 0.6792 | 1.6896 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10880.153 | 0.5388 | 0.3870 | 1.6896 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10581.141 | 0.9712 | 0.9095 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10581.141 | 0.9495 | 0.8424 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10581.141 | 0.9947 | 0.9833 | 0.6310 | |
| BT-20 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10581.141 | 1.0221 | 1.0705 | 0.6310 |