Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.0107 | uM | 7878.016 | 1.0031 | 1.0044 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.0533 | uM | 7878.016 | 0.9187 | 0.8837 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.267 | uM | 7878.016 | 1.0220 | 1.0309 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 1.33 | uM | 7878.016 | 0.9964 | 0.9949 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 6.67 | uM | 7878.016 | 1.0358 | 1.0503 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 33.3 | uM | 7878.016 | 0.8973 | 0.8526 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7878.016 | 0.9075 | 0.8674 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.000427 | uM | 7882.016 | 0.9709 | 0.9466 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.00213 | uM | 7882.016 | 0.9817 | 0.9663 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.0107 | uM | 7882.016 | 0.9829 | 0.9686 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.0533 | uM | 7882.016 | 0.9479 | 0.9043 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 0.267 | uM | 7882.016 | 0.8986 | 0.8132 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 1.33 | uM | 7882.016 | 0.9529 | 0.9134 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 6.67 | uM | 7882.016 | 0.9743 | 0.9528 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 33.3 | uM | 7882.016 | 0.3457 | -0.2448 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 167 | uM | 7882.016 | 0.4769 | 0.0142 | 1.0905 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 7884.016 | 1.0533 | 1.2388 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 7884.016 | 0.9890 | 0.9525 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 7884.016 | 1.0694 | 1.3141 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 7884.016 | 1.0412 | 1.1832 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 7884.016 | 0.9798 | 0.9133 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 7884.016 | 0.7845 | 0.1802 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 7884.016 | 0.2876 | -0.8666 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 7884.016 | 0.3238 | -0.8275 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7884.016 | 0.1869 | -0.9477 | 0.4603 |