Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | PD 98059 | MEK | MAPK | 4 | uM | 12098.159 | 0.9951 | 0.9904 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | PD 98059 | MEK | MAPK | 20 | uM | 12098.159 | 0.6574 | 0.3290 | 1.0261 | |
| SUM225CWN | HER2amp | Basal A | PD 98059 | MEK | MAPK | 100 | uM | 12098.159 | 0.6984 | 0.4097 | 1.0261 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 0.000128 | uM | 11058.152 | 0.9603 | 0.9614 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 0.00064 | uM | 11058.152 | 1.0095 | 1.0091 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 0.0032 | uM | 11058.152 | 0.9672 | 0.9682 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 0.016 | uM | 11058.152 | 0.9619 | 0.9630 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 0.08 | uM | 11058.152 | 0.9640 | 0.9651 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 0.4 | uM | 11058.152 | 0.9624 | 0.9635 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 2 | uM | 11058.152 | 0.9642 | 0.9653 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 10 | uM | 11058.152 | 0.9611 | 0.9622 | 2.0809 | |
| SUM229PE | TNBC | - | PD 98059 | MEK | MAPK | 50 | uM | 11058.152 | 0.9109 | 0.9123 | 2.0809 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 10695.152 | 0.9901 | 0.9842 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 10695.152 | 0.9945 | 0.9912 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 10695.152 | 0.9580 | 0.9325 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 10695.152 | 0.9626 | 0.9399 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 10695.152 | 0.9930 | 0.9887 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 10695.152 | 0.9860 | 0.9776 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 10695.152 | 1.0262 | 1.0418 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 10695.152 | 0.8130 | 0.6946 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 10695.152 | 0.5726 | 0.2801 | 1.2495 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.000256 | uM | 11852.159 | 0.9605 | 0.9401 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.00128 | uM | 11852.159 | 0.9384 | 0.9063 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.0064 | uM | 11852.159 | 0.9536 | 0.9296 | 1.3247 | |
| SUM52PE | HR+ | Luminal | PD 98059 | MEK | MAPK | 0.032 | uM | 11852.159 | 0.9564 | 0.9339 | 1.3247 |