Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0107 | uM | 5909.086 | 0.7607 | 0.7987 | 2.5783 | |
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0533 | uM | 5909.086 | 0.5684 | 0.6065 | 2.5783 | |
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.267 | uM | 5909.086 | 0.3580 | 0.3428 | 2.5783 | |
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 1.33 | uM | 5909.086 | 0.2584 | 0.1833 | 2.5783 | |
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 6.67 | uM | 5909.086 | 0.2289 | 0.1289 | 2.5783 | |
| BT-549 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 33.3 | uM | 5909.086 | 0.1960 | 0.0630 | 2.5783 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10473.087 | 1.0316 | 1.0544 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10473.087 | 1.0468 | 1.0804 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10473.087 | 1.0817 | 1.1401 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10473.087 | 1.0950 | 1.1628 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10473.087 | 0.8450 | 0.7295 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10473.087 | 0.4224 | -0.0491 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10473.087 | 0.1642 | -0.5792 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10473.087 | 0.0850 | -0.7616 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10473.087 | 0.0639 | -0.8136 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10755.087 | 0.9430 | 0.8475 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 10755.087 | 0.9153 | 0.7746 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 10755.087 | 0.9885 | 0.9691 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 10755.087 | 0.9366 | 0.8305 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 10755.087 | 0.8341 | 0.5652 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.267 | uM | 10755.087 | 0.3694 | -0.4794 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 10755.087 | 0.1532 | -0.8415 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 10755.087 | 0.0751 | -0.9395 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 10755.087 | 0.0532 | -0.9621 | 0.7400 | |
| HCC1143 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7430.086 | 1.0233 | 1.0259 | 1.7884 |