Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7499.066 | 0.9774 | 0.9431 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7499.066 | 0.9381 | 0.8448 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7499.066 | 0.9196 | 0.7991 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7499.066 | 0.9811 | 0.9524 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7499.066 | 0.9438 | 0.8591 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7499.066 | 0.8699 | 0.6773 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7499.066 | 0.6578 | 0.1784 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7499.066 | 0.4890 | -0.1899 | 0.7917 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7500.066 | 1.0653 | 1.1689 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7500.066 | 1.1119 | 1.2911 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7500.066 | 0.9292 | 0.8203 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7500.066 | 1.0492 | 1.1269 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7500.066 | 1.0396 | 1.1020 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7500.066 | 0.9799 | 0.9486 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7500.066 | 0.8721 | 0.6782 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7500.066 | 0.8026 | 0.5089 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 66.7 | uM | 7500.066 | 0.4758 | -0.2280 | 0.7802 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000171 | uM | 7504.066 | 1.1362 | 1.1430 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.000853 | uM | 7504.066 | 1.2318 | 1.2387 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7504.066 | 1.1412 | 1.1481 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.0213 | uM | 7504.066 | 1.2532 | 1.2597 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.107 | uM | 7504.066 | 1.2164 | 1.2236 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 0.533 | uM | 7504.066 | 1.0397 | 1.0426 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 2.67 | uM | 7504.066 | 1.1893 | 1.1966 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 13.3 | uM | 7504.066 | 1.0078 | 1.0085 | 1.8487 |