Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12400.135 | 0.9924 | 0.9883 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12400.135 | 0.9778 | 0.9657 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12400.135 | 0.9983 | 0.9974 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12400.135 | 0.9825 | 0.9730 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12400.135 | 0.8345 | 0.7396 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12400.135 | 0.1671 | -0.4967 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12400.135 | 0.0535 | -0.7910 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12400.135 | 0.0551 | -0.7861 | 1.2966 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12400.135 | 0.0395 | -0.8344 | 1.2966 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10694.148 | 0.8589 | 0.8802 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10694.148 | 0.9079 | 0.9230 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10694.148 | 0.9021 | 0.9181 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10694.148 | 0.9220 | 0.9352 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10694.148 | 0.7092 | 0.7395 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10694.148 | 0.3865 | 0.3595 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10694.148 | 0.2256 | 0.0925 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10694.148 | 0.0980 | -0.2212 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10694.148 | 0.0744 | -0.3037 | 2.4626 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10816.148 | 1.2081 | 1.5821 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10816.148 | 1.1269 | 1.3502 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10816.148 | 1.2680 | 1.7564 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10816.148 | 1.0583 | 1.1590 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10816.148 | 0.9101 | 0.7611 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10816.148 | 0.3778 | -0.4631 | 0.7402 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10816.148 | 0.2550 | -0.6843 | 0.7402 |