Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 11852.158 | 1.0378 | 1.0571 | 1.3172 | |
| SUM52PE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 11852.158 | 0.7683 | 0.6373 | 1.3172 | |
| SUM52PE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 11852.158 | 0.1226 | -0.5934 | 1.3172 | |
| SUM52PE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 11852.158 | 0.0107 | -0.9362 | 1.3172 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 12608.165 | 0.9736 | 0.9605 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 12608.165 | 0.9118 | 0.8669 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 12608.165 | 0.9701 | 0.9552 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 12608.165 | 0.9485 | 0.9227 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 12608.165 | 0.9649 | 0.9473 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 12608.165 | 0.9942 | 0.9913 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 12608.165 | 0.9128 | 0.8684 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 12608.165 | 0.0157 | -0.9100 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 12608.165 | 0.0125 | -0.9240 | 1.3403 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 11938.158 | 0.9180 | 0.7276 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 11938.158 | 0.8619 | 0.5512 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 11938.158 | 0.8823 | 0.6143 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 11938.158 | 0.7226 | 0.1473 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 11938.158 | 0.4363 | -0.5161 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 11938.158 | 0.4089 | -0.5668 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 11938.158 | 0.3020 | -0.7421 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 11938.158 | 0.0124 | -0.9989 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 11938.158 | 0.0077 | -0.9995 | 0.5846 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 12003.165 | 0.9834 | 0.9677 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 12003.165 | 0.9669 | 0.9354 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 12003.165 | 0.8969 | 0.7988 | 1.0267 |