Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12333.167 | 0.5005 | -0.2763 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12333.167 | 0.2401 | -0.7539 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12333.167 | 0.0274 | -0.9898 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12333.167 | 0.0189 | -0.9941 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12333.167 | 0.0216 | -0.9929 | 0.6809 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12414.167 | 0.9921 | 0.9869 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12414.167 | 0.9600 | 0.9337 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12414.167 | 1.0340 | 1.0559 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12414.167 | 1.0708 | 1.1160 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12414.167 | 0.5830 | 0.2819 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12414.167 | 0.0185 | -0.9254 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12414.167 | 0.0109 | -0.9520 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12414.167 | 0.0156 | -0.9352 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12414.167 | 0.0157 | -0.9349 | 1.2130 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10874.154 | 0.9947 | 0.9862 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.000427 | uM | 10874.154 | 1.0170 | 1.0446 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.00213 | uM | 10874.154 | 1.0040 | 1.0105 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0107 | uM | 10874.154 | 1.0231 | 1.0606 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.0533 | uM | 10874.154 | 0.8441 | 0.6021 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 0.267 | uM | 10874.154 | 0.2837 | -0.6156 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 1.33 | uM | 10874.154 | 0.0310 | -0.9788 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 6.67 | uM | 10874.154 | 0.0214 | -0.9870 | 0.7639 | |
| MX1 | Unknown | Unknown | LBH589 | HDAC | HDAC | 33.3 | uM | 10874.154 | 0.0147 | -0.9921 | 0.7639 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11851.154 | 0.9547 | 0.9227 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 11851.154 | 1.0001 | 1.0001 | 1.1765 |