Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 10755.154 | 0.9041 | 0.8116 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 10755.154 | 0.8968 | 0.7974 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 10755.154 | 0.1621 | -0.6642 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 10755.154 | 0.0840 | -0.8237 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 10755.154 | 0.1039 | -0.7830 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 10755.154 | 0.1386 | -0.7120 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12070.154 | 0.9629 | 0.9325 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12070.154 | 1.0274 | 1.0497 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.00213 | uM | 12070.154 | 1.0726 | 1.1316 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0107 | uM | 12070.154 | 0.9277 | 0.8682 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.0533 | uM | 12070.154 | 0.3184 | -0.2931 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 0.267 | uM | 12070.154 | 0.0118 | -0.9647 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 12070.154 | 0.0169 | -0.9508 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 12070.154 | 0.0418 | -0.8882 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 12070.154 | 0.0367 | -0.9008 | 1.1006 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12112.154 | 0.9514 | 0.9463 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 12112.154 | 0.8903 | 0.8771 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 12112.154 | 1.0552 | 1.0595 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 12112.154 | 0.9701 | 0.9671 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 12112.154 | 0.7047 | 0.6523 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 12112.154 | 0.2922 | 0.0218 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 12112.154 | 0.0988 | -0.4346 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 12112.154 | 0.1020 | -0.4248 | 1.8321 | |
| HCC1143 | TNBC | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 12112.154 | 0.0851 | -0.4790 | 1.8321 | |
| HCC1187 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10753.154 | 1.0477 | 1.0656 | 1.4444 |