Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7493.098 | 0.9772 | 0.9546 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7493.098 | 0.9800 | 0.9602 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7493.098 | 0.9352 | 0.8709 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7493.098 | 0.9676 | 0.9356 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7493.098 | 0.9330 | 0.8667 | 1.0051 | |
| MCF7 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7493.098 | 0.8700 | 0.7411 | 1.0051 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7494.098 | 0.9454 | 0.8880 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7494.098 | 0.9380 | 0.8728 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7494.098 | 0.9861 | 0.9715 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7494.098 | 1.0112 | 1.0230 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7494.098 | 0.9586 | 0.9150 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7494.098 | 0.9560 | 0.9098 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7494.098 | 0.9466 | 0.8906 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7494.098 | 0.9979 | 0.9958 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7494.098 | 0.9903 | 0.9802 | 0.9748 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7495.098 | 0.7335 | 0.1765 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7495.098 | 1.6224 | 3.5793 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7495.098 | 1.3398 | 2.3001 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7495.098 | 1.0000 | 1.0000 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7495.098 | 1.1986 | 1.7272 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7495.098 | 1.1339 | 1.4800 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7495.098 | 1.0223 | 1.0771 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7495.098 | 0.9687 | 0.8940 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7495.098 | 1.0139 | 1.0477 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7496.098 | 1.0249 | 1.0552 | 0.9037 |